从风险到慢性:对精神分裂症中自发大脑活动的演变模式的遗传和神经成像洞察
Yijing Zhang1, He Wang1, Mengjing Cai2
1Department of Radiology and Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, China.
Psychological medicine
|October 10, 2025
概括
精神分裂症阶段显示出明显的脑活动变化. 与这些变化相关的基因可以作为精神分裂症的普遍生物标志物和治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症通过不同的阶段进展:高风险,第一次发作和慢性.
- 每个阶段都表现出改变的自发大脑活动,可以通过静止状态的功能性MRI检测到.
- 这些大脑活动变化的遗传基础在很大程度上仍未被探索.
研究的目的:
- 在精神分裂症的各个阶段进行自发大脑活动改变的元分析.
- 使用全基因组关联研究 (GWAS) 数据识别与精神分裂症相关的基因.
- 确定与大脑活动相关的基因,以确定潜在的治疗向.
主要方法:
- 一个对52项神经成像研究的元分析,研究精神分裂症的阶段.
- 全基因组关联研究 (GWAS) 总结统计和基因标识的基因组注释 (H-MAGMA) 的Hi-C合多标记分析.
- 转录组神经成像协会和基因优先级分析将基因与大脑活动联系起来.
主要成果:
- 在高风险,首发和慢性精神分裂症阶段观察到明显的脑活动模式.
- 特定的区域,如右中间带状环,右门和右下额头,显示出改变的活动.
- 确定了199个与大脑活动变化相关的基因,涉及神经发育和突触功能.
结论:
- 大脑活动的改变是特定于阶段的,但在精神分裂症的进展中始终存在联系.
- 鉴定出来的基因代表了精神分裂症诊断和治疗的潜在的普遍生物标志物.
- 这些发现为精神分裂症干预提供了新的治疗目标.
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