上呼吸道炎症在自身免疫性疾病中的不同风险模式:全国性的回顾性分析
Jessan A Jishu1, Cameron Galic1, Abdelrahman Shata2
1Tulane University School of Medicine, New Orleans, Louisiana.
American journal of rhinology & allergy
|October 10, 2025
概括
大多数自身免疫性疾病 (ADs) 降低了上呼吸道炎症 (UAI) 的风险. 然而,特定的疾病,如血管炎增加UAI的风险,表明复杂的疾病相互作用.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 流行病学 流行病学
背景情况:
- 自身免疫性疾病 (ADS) 的特点是系统性炎症.
- 阿尔茨海默病与上呼吸道炎症 (UAI) 之间的关系需要进一步描述.
研究的目的:
- 调查各种ADs之间的关联以及随后UAI的发展.
- 与对照组相比,分析UAI在大量AD患者队列中的发生率.
主要方法:
- 使用TriNetX.的非识别电子健康记录进行的回顾性队列研究.
- 包括被诊断患有一种或多种AD的青少年和成年患者.
- 12个月的洗期排除了先前存在的UAI;主要结局是UAI发生率.
主要成果:
- 与对照组 (13.81%) 相比,AD患者的UAI总发病率明显较低 (9.11%).
- 在过敏性鼻炎和慢性鼻炎中观察到UAI风险降低.
- 带有多炎的颗粒状瘤和带有多炎的eosinophilic颗粒状瘤与UAI风险增加有关.
结论:
- 大多数AD与发展UAI的风险降低有关.
- 某些自身免疫性血管类提升了UAI的风险,这表明疾病特异性机制.
- 系统性自身免疫和UAI之间的复杂相互作用需要进一步研究机制和治疗方法.
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