系统性疾病与口腔状体疾病的关联:一项回顾性病例对照研究
Mari Vehviläinen1, Tuomas Selander2, Tuula Salo3,4,5
1Department of Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Oral diseases
|October 10, 2025
概括
口腔状体病变 (OLL) 与自身免疫性甲状腺功能低下症有关,而口腔平体 (OLP) 与过敏有显著的关联. 对OLP和甲状腺功能低下的进一步研究没有统计学意义.
科学领域:
- 口服药是一种口服药.
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔平状 (OLP) 和口腔状 (OLL) 病变是影响口腔粘膜的炎症状况.
- 与OLP和OLL相关的并发症需要进一步调查,以了解它们的潜在机制和临床影响.
研究的目的:
- 为了研究口腔平坦 (OLP) 和口腔状 (OLL) 病变与各种并发症之间的关联.
- 确定自身免疫性甲状腺功能低下症和过敏是否与OLP和OLL有显著的关联.
主要方法:
- 对205名OLP患者,96名OLL患者和301名对照进行了病例控制研究.
- 收集的数据包括病史,药物,过敏,全身平坦,以及口腔病变的临床特征.
主要成果:
- 自免疫性甲状腺功能低下的患病率在OLP中为12.2%,在OLL中为18.8%,在对照中为9%. OLL显示与甲状腺功能低下症有显著的关联 (OR 2.292,p=0.015).
- 与对照组 (22.9%) 相比,OLP患者 (36.1%) 的过敏更为普遍,具有显著的关联 (OR 1.872,p=0.003).
- 在OLP和甲状腺功能低下之间没有发现统计学意义上的关联 (OR1.425,p=0.237). 侵蚀性OLP病变在甲状腺功能低下症患者中更为常见.
结论:
- 口腔状体病变 (OLL) 与自身免疫性甲状腺功能低下症有显著的关联.
- 过敏与口腔平坦 (OLP) 有着显著的关联.
- 在这项研究中,口腔平坦菌 (OLP) 和自身免疫性甲状腺功能低下症之间的关联在统计学上并不显著.
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