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细菌参与口腔状细胞癌和潜在的恶性口腔疾病

Atsumu Koketsu¹, Satoshi Fukase¹, Toru Tamahara²

¹Division of Oral and Maxillofacial Oncology and Surgical Sciences, Department of Disease Management Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Miyagi, Japan.

|October 10, 2025

概括

口腔的微生物组

科学领域:

微生物组研究的研究.
口腔瘤学在口腔瘤学
转基因组学是指转基因组学.

背景情况:

口腔状细胞癌 (OSCC) 和潜在的恶性口腔疾病 (OPMD) 是严重的健康问题.
口腔细菌菌群在OSCC和OPMD发育和进展中的作用仍然不完全理解.

研究的目的:

研究OPMD,早期OSCC和高级OSCC患者的口腔微生物群组成和多样性之间的关联.
探索唾液微生物组作为口腔癌检测和进展的生物标志物的潜力.

主要方法:

横截面观察性研究涉及50个对照组,77名OPMD患者,41名早期OSCC患者和20名晚期OSCC患者.
使用16S rRNA基因安普利康序列测序分析的唾液样本用于口腔微生物组概况.
甲基因组学分析以确定细菌的组成和多样性,在类和属的水平.

主要成果:

与早期OSCC和OPMD组相比,先进的OSCC患者表现出明显更高的口腔细菌多样性.
基于口腔微生物组概况的高级OSCC组的明显聚类.
在早期OSCC/OPMD群体中增加了Actinomycetia和Streptococcus的水平;在晚期OSCC中增加了Peptostreptococcus和Fusobacterium.

结论:

口腔微生物群的组成和多样性与OPMD的发展和OSCC的进展有关.
唾液微生物组显示为早期口腔癌检测和预测疾病进展的潜在生物标志物具有前途.

关键词:

血清白血病 (leukoplakia) 是一种病.我们的微生物群.口腔中的瘤.口腔癌是口腔癌的一种疾病.口腔平坦 (OLP) 是一种口腔潜在恶性疾病 (OPMDs)头部和部的状细胞癌.

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