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鱼的数量,也是 - REACH水生毒性测试的动物损失

Jean Knight¹, Costanza Rovida^2,3, Kate Willett⁴

¹Consultant, Half Moon Bay, CA, USA.

|October 10, 2025

概括

欧洲联盟欧洲联盟

科学领域:

环境科学环境科学
毒理学毒理学毒理学
监管科学监管科学

背景情况:

欧盟的化学品登记,评估,授权和限制 (REACH) 规定要求进行化学品安全评估.
虽然经常讨论哺乳动物测试,但鱼类测试是REACH评估的重要组成部分.
目前的REACH法规严重依赖于动物试验来评估化学物质的影响.

研究的目的:

为量化根据REACH法规测试中使用的鱼类数量.
预测监管变化对鱼类测试要求的未来影响.
倡导在化学安全评估中采用非动物替代品.

主要方法:

根据REACH提交的直接测试报告的分析.
根据已完成,正在进行和正在进行的测试,估计鱼类数量.
根据监管修正和修订,预测未来的测试需求.

主要成果:

迄今为止,大约有382,000只鱼类被用于各种REACH测试.
即将到来的REACH修正案可能需要520,000680,000额外的鱼类进行长期毒性测试.
目前的计数排除了内分泌干扰测试的潜在增加.

结论:

在REACH化学品安全评估中,大量的鱼类被使用.
监管变化将大幅增加鱼类测试需求.
开发和实施非动物替代品对于减少动物使用和与REACH原则保持一致至关重要.

关键词:

在REACH系统中,我们可以使用REACH.其他方法替代方法鱼类毒性测试鱼类毒性测试

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