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肠道微生物群Lactobacillus acidophilus及其与甲状腺结节和甲状腺激素特征的关系
Mohamed Abd ElFatah Mohamed Mojahed Eladly1, Hadia Elsayed Morsy2, Inas Mohamed Sabry Elnabrawy2
1Faculty of Medicine, Kafr Elsheikh University, Kafr Elsheikh, Egypt. mohamedeladly810@gmail.com.
Endokrynologia Polska
|October 10, 2025
概括
这项研究研究了肠道细菌Lactobacillus acidophilus与甲状腺结节的关系. 研究结果表明,甲状腺结节患者和健康人群之间的Lactobacillus acidophilus水平存在显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 甲状腺疾病与甲状腺激素水平和肠道微生物组合有关.
- 之前的研究已经确定了肠道微生物群与格雷夫斯病或哈希莫托甲状腺炎之间的联系.
- 肠道微生物群和甲状腺结节之间的关系在很大程度上仍未被探索.
研究的目的:
- 为了研究Lactobacillus acidophilus和甲状腺结节之间的相关性.
- 在患有甲状腺结节的患者中分析Lactobacillus acidophilus水平和甲状腺激素概况之间的关联.
主要方法:
- 在2021-2022年间进行的一项前性病例控制研究,涉及90名参与者.
- 参与者被分为三组:良性甲状腺结节 (A组),恶性甲状腺结节 (B组) 和对照组 (C组).
- 测量包括激素特征,血清标记 (,,抗TPO) 和便聚合酶连锁反应 (PCR) 的Lactobacillus acidophilus.
主要成果:
- 在这三个组中观察到Lactobacillus acidophilus PCR循环值 (CT) 的显著变化.
- A组 (良性结节) 的CT为32.340±5.025,B组 (恶性结节) 的CT为34.957±5.834,C组 (对照组) 的CT为27.530±5.834 (p<0.001).
结论:
- 通过PCR评估的Lactobacillus acidophilus的便水平显示,在甲状腺结节和没有甲状腺结节的个体之间存在显著差异.
- 这些发现表明Lactobacillus acidophilus在甲状腺结节的发展或存在的背景下可能发挥作用.
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