新的高特异性纤维具有强烈和一致的响应跨个体
Mirian Aparecida de Campos Costa1,2, Xinruo Zhao1, Dirce Komura3
1Whistler Center for Carbohydrate Research and Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907, USA. tcantuju@purdue.edu.
Food & function
|October 10, 2025
概括
新的高特异性益生菌纤维,如 Acacia 和 Fucogalactan 促进了持续的肠道微生物组转变. 这些纤维通过向特定的有益细菌来提供可预测的健康益处,与不太具体的选择不同.
科学领域:
- 微生物组研究的研究.
- 食纤维科学 食纤维科学
- 益生菌干预措施 益生菌干预措施
背景情况:
- 肠道微生物群的个体变异性阻碍了益生菌纤维干预的持续健康益处.
- 纤维层次特异性描述了细菌对纤维的选择性利用.
- 识别高特异性的纤维对于可预测的益生菌效应至关重要.
研究的目的:
- 评估新型的高特异性纤维对一致的肠道微生物调节.
- 评估候选纤维诱导个人之间可预测和强烈的微生物转移的能力.
- 将六种候选纤维的疗效与低特异性和高特异性的参考纤维进行比较.
主要方法:
- 在体外测试六种候选纤维 (阿卡西亚,富科加拉克坦,格兰,瓜尔,豆,西洛利戈糖) 使用来自十个捐赠者的便微生物群.
- 与参考纤维的比较:果类糖 (低特异性) 和一种不溶性葡萄糖 (高特异性).
- 对短链脂肪酸 (SCFA) 生产和微生物属丰富的分析.
主要成果:
- 富科加拉克坦和瓜尔具有强烈的益生性; 亚卡西亚和龙豆促进了平衡的SCFA生产. 格兰显示出最小的发酵.
- 阿卡西亚,Fucogalactan,Guar,和豆始终丰富特定的有益的属 (例如,艾森伯吉拉,Hungatella).
- 这四种纤维在所有捐赠者中表现出强烈,一致的反应,这与高特异性纤维的特征不同,与果和氧不同.
结论:
- 亚卡西亚,Fucogalactan,Guar和Locust豆被确定为具有高特异性的纤维.
- 这些纤维在肠道微生物群中诱导了一致的,以分类为目标的变化.
- 它们扩大了可预测的微生物群调节和潜在的健康结果的选择.
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