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非注射式胺用于急诊室的儿科镇静:系统性审查
Hadi Mirfazaelian1,2, Alireza Erfan Fazel3, Nima Azizi3
1Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran.
概括
非注射式胺 (NIK) 在儿科急诊室提供有效的程序镇静和止痛 (PSA). 口服胺提供了可取的镇静作用,更快的开始和更短的持续时间,而NIK似乎对儿童的PSA安全.
科学领域:
- 儿科急救医学 儿科急救医学
- 药理学 药理学是指药理学的学科.
- 系统审查是系统的审查.
背景情况:
- 胺是儿科急诊室 (ED) 程序性镇静和止痛 (PSA) 的常见药物.
- 与胺注射相关的疼痛需要探索替代的注射途径.
- 非注射式胺 (NIK) 的使用需要进一步评估.
研究的目的:
- 系统地审查非注射式胺 (NIK) 用于儿科手术镇静和止痛 (PSA) 的细节.
- 评估NIK在急诊室环境中的儿科患者的疗效和安全性.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在MEDLINE,Embase,Cochrane,Web of Science和Scopus数据库中进行了搜索.
- 包括ED中儿科人群中PSA的NIK原始临床研究;评估偏差风险和证据确定性 (COE).
主要成果:
- 包括12项研究 (1484名患者),主要评估口服胺在2至12岁儿童的伤修复方面.
- 与口服比较者相比,口服胺 (5-10 mg/kg) 显示出理想的镇静作用 (COE:非常低),更快的开始 (15-35 分钟) 和更短的持续时间 (60-265 分钟) (COE:低).
- 在PSA (COE:中度至低) 期间,没有报告口服和鼻腔胺的严重不良事件 (SAE).
结论:
- 口服胺可以提供有效的镇静,与儿科PSA的口服药物相比,其开始和持续时间有所改善.
- 非注射式胺 (NIK) 似乎是安全的,在程序镇静和止痛期间没有报告的SAEs.
- 有限且异质的研究需要进一步的研究来证实关于NIK有效性和安全性的发现.
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