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[关于在慢性病患者中使用加多基对比剂]

François Cousin¹, Martin Moïse^1,2, Cédric Ilbert³

¹Services de Médecine Nucléaire et Imagerie Oncologique, CHU de Liège, Belgique.

Revue medicale de Liege

|October 10, 2025

概括

基于加多的对比剂 (GBCA) 在慢性病 (CKD) 患者的磁共振成像 (MRI) 中更安全. 宏环GBCA提供了更好的稳定性和减少组织积累,最大限度地降低了与MRI对比剂相关的风险.

科学领域:

放射学和医学成像学医学成像学
腎臟病學 (nephrology) 是一種醫學.
药理学药理学是指药理学的学科.

背景情况:

基于加多的对比剂 (GBCA) 对于磁共振成像 (MRI) 非常重要.
由于原体系统性纤维化风险,人们对慢性病 (CKD) 患者的GBCA安全性存在担忧.
由于不稳定性和组织保留风险,欧洲药品管理局 (EMA) 在2017年禁止了线性GBCA.

研究的目的:

在慢性病 (CKD) 患者中评估现代基对比剂 (GBCA) 的安全性.
评估加多 (Gd3+) 积累的风险和CKD患者的相关临床后果.
突出宏环GBCA在MRI程序中的优势,而不是线性GBCA.

主要方法:

最近关于加多 (Gd3+) 积累在正常和功能受损的患者中的研究的综述.
对线性与宏环性GBCA的化学稳定性和组织保留性能的分析.
评估GBCA在慢性病患者中使用的益处风险比率.

主要成果:

与线性GBCA相比,宏环GBCA表现出优越的稳定性和显著降低的加多 (Gd3+) 分离和组织积累.
在重复使用线性GBCA后观察到基底中加多 (Gd3+) 积累,即使在具有正常功能的患者中,也没有证明临床后果.
质性系统性纤维化风险在现代宏环性GBCA的使用下大大降低,即使在CKD患者中也是如此.

结论:

使用宏环加基对比剂 (GBCA) 的MRI在经过仔细的益处风险评估和剂量限制后,被认为对慢性病 (CKD) 患者是安全的.
宏环GBCA的增强稳定性将加多 (Gd3+) 解离和随后的组织积累的风险降至最低.
在GBCA技术的进步显著改善了安全性,使MRI成为CKD患者的可行选择.

关键词:

慢性脏疾病慢性脏疾病对比剂是一种对比剂.在加多利尼姆 (Gadolinium) 中.核磁共振成像技术核磁共振成像技术安全的安全的安全的安全的安全.

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