苏马克 (Rhus coriaria L) 补充对成年人高敏感性C反应性蛋白度:系统性审查和剂量反应元分析
Mostafa Shahraki Jazinaki1,2, Hossein Bahari1,2, Iman Rahnama2
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Current developments in nutrition
|October 10, 2025
概括
在成年人中,补充黄可显著降低高灵敏性C反应蛋白 (hs-CRP) 水平,表明潜在的抗炎作用. 需要进一步的研究来证实这些发现,并确定降低炎症的最佳使用.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 慢性轻度炎症与代谢和心血管疾病有关.
- (Rhus coriaria L.) 是一种药用植物,已有记录的抗炎性质.
- 苏玛克对像hs-CRP这样的炎症生物标志物的影响尚未完全理解.
研究的目的:
- 系统地审查和分析补充苏玛克对成年人hs-CRP度的影响.
- 巩固来自随机对照试验 (RCT) 的证据.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane图书馆数据库中进行系统搜索.
- 在查和偏差风险评估后包括七个RCT.
- 随机效应模型用于元分析,以计算整体效应大小 (SMD).
主要成果:
- 与对照组相比,补充黄素显著降低了hs-CRP度 (SMD: -0.33;P=0.03).
- 在包括的研究中观察到显著的异质性 (I2=60.2%).
- 亚组分析显示,在特定人群中 (两种性别,NAFLD患者,超重个体和≥45岁的患者) 显著减少.
结论:
- 补充 Sumac 在降低成人 hs-CRP 水平方面显示出有希望.
- 需要进一步进行高质量的大规模试验来验证这些结果.
- 最佳剂量和持续时间的抗炎作用需要进一步调查.
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