表面活性剂对波萨可纳结晶和多态性的影响:Tween 80与Span 80之间
Kennedy A Borchardt-Setter1, Xin Yao1,2, Rose K Cersonsky3
1School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Crystal growth & design
|October 10, 2025
概括
像Span 80和Tween 80这样的表面活性剂会影响波萨可纳结晶率. 经典核化理论准确地模拟了这些效应,揭示了不同波萨可纳多态的不同界面张力.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 物理化学 物理化学
背景情况:
- 表面活性剂在制药配方中很常见.
- 表面活性剂可以显著改变药物结晶过程.
- 了解表面活性剂的作用对于控制药物的固态特性至关重要.
研究的目的:
- 调查Span 80和Tween 80对波萨可纳 (POS) 结晶的影响.
- 分析这些表面活性剂对POS多态I和POS多态II的核和生长动力学的影响.
- 评估古典核化理论 (CNT) 在表面活性剂杂系统中的适用性.
主要方法:
- 研究了波萨可纳在纯净和涂有表面活性剂的融物中的结晶动力学 (0-10重量百分比Span 80和Tween 80).
- 测量了波萨可纳多态I和II的核化和生长速度.
- 应用经典核化理论 (CNT) 来建模核化动力学和确定界面张力.
主要成果:
- 这两种表面活性剂都增加了类似的多态生长率,但影响了不同的核化率.
- CNT 量化描述了核化动力学,将表面活性剂视为理想的稀释剂.
- 界面张力 (σ) 被确定为: 形式I的0.019 J/m2和形式II的0.012 J/m2.
- 化的形式I的较高σ表明与不纯的结构差异较大.
结论:
- 经典核化理论为理解表面活性剂对多态结晶的影响提供了一个强大的框架.
- 表面活性剂可以在CNT中作为理想稀释剂进行建模,用于预测核化动力学.
- 该研究提供了表面活性剂对多态结晶的影响的简化模型,这对于制药配方开发至关重要.
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