贝瓦西祖马布后的无菌内炎的完整和早期玻璃切除术:一个案例系列
Agnieszka Kudasiewicz-Kardaszewska1, Malgorzata A Ozimek1, Aleksandra Kardaszewska2
1Ophthalmology, Professor Zagórski Eye Surgery Centre, OCHO Medical Group, Nowy Sącz, POL.
Cureus
|October 10, 2025
概括
在抗VEGF注射后的无菌内炎可以模仿感染. 使用CEVE协议的早期帕斯普拉纳视切除术有效地解决了5名患者的炎症并恢复了视力,这表明免疫媒介的原因.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 炎症条件 炎症条件
背景情况:
- 静脉内抗VEGF注射是视网膜疾病的标准.
- 无菌内耳炎是一种罕见但严重的并发症,难以区分于传染性内耳炎.
- 贝瓦西祖马布经常用于网膜疾病的非标签.
研究的目的:
- 描述了一系列经历了bevacizumab注射后急性眼内炎症的患者.
- 评估完整和早期玻璃切除术对内眼炎 (CEVE) 协议在管理这些病例中的有效性.
- 调查潜在的机制背后的注射后无菌内.
主要方法:
- 在bevacizumab注射后48小时内出现急性眼内炎症的5名患者的病例系列.
- 紧急的帕斯普拉纳视切除术按照CEVE协议进行,包括手术内注射抗生素和微生物采样.
- 记录了临床表现,管理和视觉结果.
主要成果:
- 患者表现出视力敏度下降和玻璃体雾,疼痛最小.
- 玻璃体和贝瓦西祖马布小瓶培养是负的,排除了感染.
- 所有患者都实现了炎症解消,并在体外切除术后的30天内恢复了基线视力敏度.
- 没有发现术后并发症.
结论:
- 这些发现支持在bevacizumab注射后无菌内甲状腺炎的免疫媒介,非传染性病因.
- 根据CEVE协议,早期玻璃切除术是一种有效的管理策略,用于快速解决和有利的视觉恢复.
- 持续的警和研究是必要的,以优化无菌内眼炎的管理.
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