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在口腔状细胞癌中MALAT1表达 - 一个系统性审查和元分析

Ija Mayuek¹, Abikshyeet Panda¹, Harish Kumar¹

¹Department of Oral and Maxillofacial Pathology and Oral Microbiology, KIIT University, Kalinga Institute of Dental Sciences (KIDS), Kalinga Institute of Industrial Technology (KIIT), Deemed to be University, Bhubaneswar, Odisha, India.

Journal of oral and maxillofacial pathology : JOMFP

|October 10, 2025

概括

转移相关的肺腺癌转录1 (MALAT1) 在口腔状细胞癌 (OSCC) 中升高,与瘤等级相关. 这一发现强调了MALAT1作为OSCC进展和转移的潜在预后标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

转移相关的肺腺癌转录1 (MALAT1) 是一种长非编码RNA,涉及到疾病预后.
了解MALAT1表达对于评估口腔状细胞癌 (OSCC) 进展至关重要.

研究的目的:

系统地审查和元分析与正常组织相比,OSCC中MALAT1的表达率.
调查MALAT1表达与不同类型的OSCC (良好,中度和差异化) 的组织病理学等级之间的相关性.

主要方法:

按照PRISMA指南进行系统审查和元分析.
从2000年1月到2024年4月,对OSCC中MALAT1表达的研究进行了数据库搜索.
使用纽卡斯尔-太华尺度 (NOS) 的质量评估和使用随机效应模型的元分析.

主要成果:

包括7项研究,其中4项正在进行元分析,表明偏差风险中等至低.
与正常组织相比,OSCC细胞中的MALAT1表达显著增加 (SMD = 3.90).
在OSCC等级中观察到MALAT1的差异表达,这表明与瘤分化的联系.

结论:

马拉特1在OSCC上升调节,在不同的组织学等级中显示不同的表达水平.
增加MALAT1表达与OSCC生长和潜在的转移有关.
马拉特1作为一个有前途的OSCC预后标记,具有显著的临床意义.

关键词:

诊断诊断诊断诊断诊断转移相关的肺腺癌转录 1 1 口腔癌是指口腔癌的发生.预后预后预后系统性审查系统性审查

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