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Updated: Jan 15, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
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Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets

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通过单细胞分析揭示了具有差异转录组的调控性CD8+ T细胞的两个子集

Céline Sérazin1, Lisa Dugast1, Léa Flippe1

  • 1Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, CNRS, 44000 Nantes, France.

iScience
|October 10, 2025
PubMed
概括

研究人员确定了两个不同的人类CD8+调节性T细胞 (Treg) 子集. 一个子集,TNFR2+CD29lowCD45RClow/-,显示出强大的抑制能力,推动了Treg研究和临床应用.

关键词:
免疫学 免疫学 免疫学文字转录学 (Transcriptomics) 是一个学科.

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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