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在患有瘤诊断的儿科患者中开发休息能量消耗的预测方程
Alda Daniela García-Guzmán1,2, Sandra Nayeli Becerra-Morales3,4, Beatriz Adriana Pinzón-Navarro2,5
1Servicio de Oncología Médica, Instituto Nacional de Pediatría, Mexico City, Mexico.
Frontiers in nutrition
|October 10, 2025
概括
新的方程准确地估计了癌症儿童的休息能量消耗 (REE),改善了营养支持. 这些专门针对儿童癌症的模型减少了营养不良的风险,并提高了治疗结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 临床营养学 临床营养学
- 代谢研究研究 代谢研究
背景情况:
- 儿童癌症显著影响营养状况,影响治疗反应和结果.
- 儿童癌症患者的营养不良,无论是营养不足还是营养过剩,都会带来风险.
- 准确评估休息能量消耗 (REE) 对这些儿童有效的营养支持至关重要.
研究的目的:
- 开发和验证用于估计儿科癌症患者REE的新式方程.
- 将这些新方程的准确性与传统的预测公式进行比较.
- 提高REE估计在儿科瘤学中的营养管理的临床实用性.
主要方法:
- 涉及最近被诊断患有癌症的儿科患者 (6至<18岁) 的截面研究.
- 收集人体测量数据,评估营养状况,并分析身体成分 (生物电阻).
- 使用间接热量计 (IC) 作为黄金标准来测量REE.
主要成果:
- 为儿童癌症患者开发了两种新的REE预测方程,INP-simple和INP-Morpho.
- 与传统方程 (例如,哈里斯-本尼迪克特,斯科菲尔德,IOM) 相比,INP方程都显示了REE估计中的偏差减少.
- 患有脑瘤的患者每公斤体重的REE较低.
结论:
- 患有癌症的儿童通常会改变能量消耗,增加营养不良的风险.
- 特定于癌症的REE预测方程可以提高临床环境中的准确性.
- 建议对这些新开发的儿科癌症REE方程进行进一步的外部验证.
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