在心力衰竭中循环生物标志物的诊断和预后价值
Artur Kovenskiy1, Zhussipbek Mukhatayev1, Aliya Sailybayeva2
1National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
Frontiers in cardiovascular medicine
|October 10, 2025
概括
生物标志物揭示了炎症的发生.
科学领域:
- 生物标志物研究的研究.
- 心血管疾病是什么心血管疾病
- 免疫学 免疫学 免疫学
背景情况:
- 心力衰竭 (HF) 是一个全球性的健康问题,基于左心室喷射率 (LVEF) 的独特表型.
- 减少喷射分数 (HFrEF) 的心力衰竭和保留喷射分数 (HFpEF) 的心力衰竭有不同的原因,并发症和对治疗的反应,尽管它们具有共同的内皮功能障碍.
研究的目的:
- 系统地审查和分析炎症,心脏重塑,拥堵和心肌损伤生物标志物,跨越HF表型.
- 整合来自78项研究的数据,其中包括58,076名受试者,以了解HF表型中的生物标志物概况.
主要方法:
- 系统审查和元分析.
- 检查炎症,心脏重塑,拥堵和心肌损伤生物标志物.
- 整合了78项研究 (58,076名受试者) 的数据.
主要成果:
- 与对照人群相比,HF患者的IL-6,TNF-alpha和hs-CRP升高.
- 在HFrEF和HFpEF表型之间有不同的生物标志物概况,尽管炎症标志物显示重叠.
- 伴随性疾病会影响炎症概况,这表明需要采用多种生物标志物方法.
- NT-proBNP,sST2,GDF-15和热素补充炎症标记物,用于精确的HF表型.
结论:
- 炎症在HF病理生理学中起着核心作用.
- 关于HFpEF特定的炎症特征存在知识差距.
- 这些研究结果支持开发针对性免疫调节疗法和个性化诊断,用于治疗HF.
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