定量13C-尿素呼吸试验值预测了Helicobacter pylori感染儿童的胃风险:一项回顾性研究
Xiaoting Pan1,2, Youtao Chen1,2, Haibo Li2
1Fujian Children's Hospital, Fujian Branch of Shanghai Children's Medical Center, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Frontiers in pediatrics
|October 10, 2025
概括
定量13C-尿素呼吸试验 (13C-UBT) 有效地诊断儿童的H. pylori感染. 最佳门与胃风险相关,有助于诊断和预后.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 传染性疾病 传染性疾病
- 诊断的准确性 诊断的准确性
背景情况:
- 13C-尿素呼吸试验 (13C-UBT) 是诊断H. pylori感染的关键工具.
- 儿科特异性诊断值及其与胃潰瘍 (PU) 疾病的联系需要进一步定义.
- 这项研究解决了对优化儿科13C-UBT标准和风险评估的需求.
研究的目的:
- 为了建立最佳的儿科delta超过基线 (DOB) 值来诊断H.pylori感染.
- 调查 DOB 值与儿童胃的风险之间的关联.
- 评估量化13C-UBT在儿科患者群体中的诊断和预后效用.
主要方法:
- 对1034名接受13C-UBT和内镜检查的儿童 (3-18岁) 的回顾性分析.
- 使用ROC分析来确定最佳的DOB截止值.
- 后勤回归和受限立方线分析评估了DOB和风险之间的关系.
主要成果:
- 儿科最优的DOB截止值为5.285‰,证明了高的诊断准确性 (灵敏度84%,特异性90%,AUC0.879).
- 与没有胃的儿童相比,患有胃的儿童的中位数DOB显著更高 (3.1%对1.9%,P<0.001).
- 观察到一种剂量与反应的关系,的风险随DOB增加到大约36.39‰,然后平稳.
结论:
- 5.285‰的DOB截止值对于诊断儿科H.pylori感染非常准确.
- 较高的DOB与细菌负载,炎症和胃潰瘍风险相关,显示和效应约为36.39‰.
- 定量DOB评估提供了有价值的诊断和预后信息,支持其在儿科指南中的使用.
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