在关节疾病中,压力和唾液皮质醇水平:一个病例控制研究
Lujain AlSahman1, Hamad AlBagieh1, Roba AlSahman2
1Oral Medicine and Diagnostic Sciences Department, College of Dentistry, King Saud University Riyadh, 57448 Riyadh, Saudi Arabia.
Journal of oral & facial pain and headache
|October 10, 2025
概括
部疾病 (TMD) 患者在一生中表现出更高的压力和皮质醇水平. 关系和伴侣压力是TMD的重要预测因素,突出了对生物心理社会方法的需求.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 口腔和牙面部外科手术
- 压力和健康研究 压力和健康研究
背景情况:
- 研究了通过压力和逆境库存 (STRAIN) 尺度测量的累积终身压力和液皮质醇水平在关节疾病 (TMD) 患者之间的关系.
- 旨在确定特定的终身压力领域,这些领域是TMD发展和严重程度的最强有力的预测因素.
研究的目的:
- 在TMD患者和健康对照者之间比较终身压力水平和唾液皮质醇度.
- 确定特定类型的终身压力因素,显著预测TMD.
主要方法:
- 招募了110名参与者的队列 (55名TMD患者,55名对照).
- 使用STRAIN问卷进行了终身压力评估.
- 唾液皮质醇水平在上午7点和上午10点通过ELISA测量;统计分析包括t测试,ANOVA和多重回归.
主要成果:
- TMD患者报告累积压力得分明显高 (11.10 ± 3.26) 比对照组 (1.43 ± 0.99).
- 肌痛小组表现出最高的压力水平 (11.69 ± 3.72),而肌肌痛患者的压力水平最低 (8.80 ± 1.14).
- 皮质醇水平在限制口腔开口 (DDWoR与LO) 的盘位移无减小组 (82.49 ± 124.34) 中最高,在肌痛患者 (4.69 ± 3.90) 中最低.
- 关系压力 (p=0.04),羞辱 (p=0.02),婚姻/伴侣压力 (p<0.001) 和与死亡有关的压力 (p=0.01) 是TMD的显著预测因素.
结论:
- 与对照人群相比,TMD患者的一生压力和皮质醇水平显著增加.
- 肌痛患者表现出复杂的压力联系,而DDWoR与LO患者表现出明显的生理应激反应.
- 关系和伴侣相关的压力被确定为TMD的关键预测因素,强调了生物心理社会模型对TMD管理的重要性.
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