儿童创伤和成人早期的亚临床催眠症:一项遗传信息研究
Irene Gonzalez-Calvo1, Angelica Ronald2, Laura Havers1
1Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Faculty of Medicine & Dentistry, https://ror.org/026zzn846Queen Mary University of London, London, UK.
概括
童年创伤与低躁狂症和双相情感障碍 (BD) 风险有关,共同的遗传因素起着重要作用. 基因与环境的相关性和相互作用,特别是与主要抑郁症多基因分数的相互作用,影响了这些关联.
科学领域:
- 精神病学是一个精神病学.
- 行为遗传学 行为遗传学
- 发展心理学 发展心理学
背景情况:
- 初步证据表明,童年创伤和青少年亚临床催眠症之间存在联系.
- 需要在成年早期进行进一步的研究来证实这种关联,并了解潜在的机制.
- 这项研究调查了将童年创伤与低躁狂症状和双相情感障碍 (BD) 风险联系起来的遗传和环境因素.
研究的目的:
- 检查共同的遗传和环境影响,儿童创伤和低躁症症状之间的关联.
- 调查童年创伤和双相情感障碍 (BD) 的高风险状态之间的关系.
- 探索基因与环境的相关性以及儿童创伤与精神疾病多基因分数 (PGS) 之间的相互作用.
主要方法:
- 利用社区双胞胎样本 (N=8,464) 通过艾文"22岁以上的生活"问卷进行童年创伤评估.
- 在26岁时使用情绪障碍问卷 (N=7,748) 评估了低情绪症状.
- 从独立的发现样本中获得精神病和神经发育状况的多基因分数 (PGS).
主要成果:
- 儿童创伤与低躁狂症状 (β=0.23) 和BD风险 (OR=1.77) 有显著的相关性.
- 这些关联的两变遗传概率估计在0.51到0.90之间,表明强烈的遗传影响.
- 检测到儿童创伤和PGS之间的基因环境相关性,用于重大抑郁障碍 (MDD),精神分裂症,多动症,焦虑症,PTSD和BD II. 发现了MDD-PGS和儿童创伤在催眠症之间显著的相互作用 (β=0.01,p<0.05).
结论:
- 共享的遗传因素部分解释了童年创伤,催眠症和BD风险之间的联系.
- 大型抑郁症多基因评分调节了童年创伤和低躁狂之间的关联.
- 这些发现突出了基因脆弱性和环境因素在催眠症和BD病因学中的复杂相互作用.
相关概念视频
Bipolar Disorder
584
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
584
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Psychological and Sociocultural Causes of Schizophrenia
436
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
436
Attention-Deficit/Hyperactivity Disorder
709
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
709
Biological Causes of Schizophrenia
454
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
454
Depressive Disorders: Etiology
406
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
406


