肠道微生物的遗传变异调节了宿主繁殖
Xiaoyue Ding1, Yalun Wu1, Dianshuang Zhou1
1Jiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, China.
Microbial biotechnology
|October 10, 2025
概括
肠道微生物的遗传变异可能会影响宿主繁殖. 发现特定的大肠杆菌菌株可以增强模型生物的生育能力和减轻生殖毒性,从而提供新的治疗途径.
科学领域:
- 微生物学 微生物学
- 生殖生物学 生殖生物学
- 遗传学 遗传学 是一个
背景情况:
- 肠-丸轴突出了肠道微生物对宿主繁殖的影响.
- 微生物遗传变异在这个轴上的确切作用尚不清楚.
- 已知环胺 (CTX) 诱导男性生殖毒性.
研究的目的:
- 研究微生物遗传变异对宿主繁殖的影响.
- 为了确定可以减轻生殖障碍的特定肠道微生物菌株.
- 探索CTX诱导的男性生殖毒性的潜在治疗应用.
主要方法:
- 利用C. elegans作为一个模型生物体.
- 选了46种大肠杆菌 (E. coli) 菌株,以检测它们对C. elegans生育能力的影响.
- 在CTX诱导的生殖毒性小鼠模型中开发和验证工程益生菌.
- 进行了全面的代谢组和转录组分析.
主要成果:
- 确定了46种大肠杆菌菌株,可以增强C. elegans的生育能力.
- 在C. elegans中发现了26种突变的大肠杆菌菌株,能够减轻CTX诱导的生殖问题.
- 一种工程化益生菌,Ecn Δpal,显著改善了CTX诱导的生殖障碍小鼠的精子生成.
- 代谢组和转录组数据表明, purin代谢有助于改善CTX诱导的男性生殖毒性.
结论:
- 肠道微生物的遗传变异在宿主繁殖中起着重要作用.
- 特定的大肠杆菌菌株及其变体显示出作为生殖健康益生菌的潜力.
- purin代谢是参与缓解CTX诱导的男性生殖毒性的关键途径.
- 这项研究为男性生殖毒性提供了新的见解和治疗策略.
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