执行功能调解前额前部兴奋抑制平衡和情绪识别在euthymic双相情感障碍中
Cheng Ying Wu1, Chih-Yu Chang2, Shyh-Yuh Wei1
1Department of Psychiatry, https://ror.org/01b8kcc49National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Psychological medicine
|October 10, 2025
概括
优性双极性障碍患者表现出受损的情绪识别,与前额叶皮层的E / I不平衡有关. 认知灵活性调解了这种关系,突出了它在双相情感障碍中社会认知缺陷中的作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 与健康对照人群相比,优发性双极性障碍 (euBD) 患者表现出神经认知和社会认知缺陷.
- 之前的研究将默认模式网络 (DMN) 刺激/抑制 (E/I) 不平衡与euBD中的执行功能联系在一起.
- 神经认知障碍通常与精神障碍中的社会认知缺陷有关.
研究的目的:
- 研究DMN中E/I不平衡与euBD中的社会认知之间的关联.
- 检查执行职能在 E/I 不平衡和社会认知缺陷之间的关系中扮演的调解角色.
- 为了了解社会认知障碍在euthymic双相情感障碍的神经支柱.
主要方法:
- 招募了75名健康对照 (HC) 和49名euBD个体.
- 评估情绪识别 (DANVA-2-TW) 和认知灵活性 (WCST).
- 在PCC和mPFC/ACC中使用1H-MRS测量脑代谢物 (谷氨酸+谷氨酸[Glx]和GABA),以计算E/I比率.
主要成果:
- euBD患者表现出较差的情绪识别 (p=0.020) 和认知灵活性 (p=0.002).
- 在euBD患者的mPFC/ACC中,在情绪识别和E/I比率之间观察到负相关性 (r=-0.30,p=0.034).
- 认知灵活性显著调解了E/I比率和情绪识别之间的关系 (Z=-2.657,p=0.007).
结论:
- 双相情绪障碍患者表现出与前额叶皮质E/I平衡改变相关的情绪识别缺陷.
- 认知灵活性是一种执行功能,它调解了E/I比对euBD情感识别准确度的影响.
- 研究结果表明,情感/情感失衡和认知灵活性受损有助于双相情感障碍的社会认知缺陷.
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