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大麻使用量测量:确定广泛的研究应用的最佳指标

Carillon J Skrzynski¹, Raeghan L Mueller², L Cinnamon Bidwell^1,3

¹Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.

Addiction (Abingdon, England)

|October 10, 2025

概括

大麻数量和频率尺度 (CQFS) 更好地预测一般大麻使用生物标志物,而时间线追溯 (TLFB) 方法更优越地评估急性大麻使用. 这两种方法都显示出与THC-COOH和THC水平的不同关联.

科学领域:

法医毒理学法医毒理学
大麻科学大麻科学
公共卫生公共卫生

背景情况:

大麻合法化增加了产品的可用性和使用.
准确测量大麻使用对于理解暴露至关重要.
像血液中的大麻素水平这样的生物标志物是暴露的关键指标.

研究的目的:

为了比较不同的大麻使用指标 (CQFS和TLFB).
检查这些指标与大麻生物标志物 (THC和THC-COOH) 之间的关联.
调查性别或年龄是否能缓和这些关联.

主要方法:

一项观察性研究涉及1090名常规大麻使用者.
使用大麻数量和频率尺度 (CQFS) 和时间线追溯 (TLFB) 收集的数据.
测量了血液中的delta-9四大麻 (THC) 和11-nor-9-carboxy-tetrahydrocannabinol (THC-COOH) 的水平.

主要成果:

与TLFB (R2=0.27) 相比,CQFS与THC-COOH (R2=0.30) 的相关性更强.
与CQFS (R2=0.21) 相比,TLFB与即时THC水平 (R2=0.24) 的相关性更强.
在男性中,CQFS总时间/天预测了THC-COOH和THC,而TLFB日/月预测了这两种生物标志物.

结论:

CQFS是一般大麻使用模式的更好的预测器.
在评估最近或急性大麻使用时,TLFB方法更有效.
这两种方法都提供了有价值的,尽管不同,关于大麻消费和暴露的见解.

关键词:

这就是为什么THCTHTHTHTHTHTH 大麻素是一种大麻素.大麻评估大麻评估大麻措施大麻措施.大麻指标大麻指标使用大麻使用大麻使用大麻

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