酒精使用障碍中皮质的脑连接:探索其与正念的关联
Niklaus Denier1,2, Kevin Zahnd1, Maria Stein1,3
1Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Addiction biology
|October 10, 2025
概括
患有酒精使用障碍 (AUD) 的患者表现出 cingulum bundle (CB) 连接受损,影响大脑网络. 这可能与较低的正念和自我效能有关,这对于清醒至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理健康 心理健康
背景情况:
- 酒精使用障碍 (AUD) 涉及影响奖励,动机和压力的失调的大脑电路.
- 正念干预措施在通过提高自我效能和戒断率来管理AUD方面表现有前途.
- 环带束 (CB) 连接关键的大脑网络,涉及正念和执行功能.
研究的目的:
- 在患有AUD的患者中调查环带束 (CB) 的结构和功能完整性.
- 在AUD中探索CB连接,正念和与禁欲相关的自我有效性之间的关系.
- 确定CB变化是否与AUD患者的注意力和自我效能降低有关.
主要方法:
- 招募了39名AUD最近戒断的住院患者和18名健康对照.
- 通过验证的自我报告问卷来评估正念和自我效能.
- 获取结构和静止状态功能性MRI数据以分析CB连接.
主要成果:
- 与对照组相比,AUD患者在CB中表现出结构和功能连接性减少.
- 结构和功能CB连接在AUD患者中显示出强烈的积极关联.
- 正念与禁欲相关的自我效能有很强的相关性;探索性分析将CB简化号码与特定的正念方面和自我效能联系起来.
结论:
- 这项研究提供了第一个证据,表明在患有AUD的患者中,有结构性和功能性带皮带束损伤.
- CB连接的变化可能是减少正念和自我效能的基础,影响从酒精使用障碍中恢复.
- 研究结果强调CB是AUD治疗干预措施的潜在神经生物学目标.
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