汉塔病毒感染后的临床过程长达20年
Leonie Kraft1, Tina Oberacker2, Andrea Schwab1
1Department of Internal Medicine and Nephrology, Robert Bosch Hospital, Stuttgart, Germany.
概括
经过病流行病 (NE) 的长期并发症并不常见,尽管经常出现高血压. 这项研究发现,在Puumala病毒感染后,慢性病发病率没有增加.
科学领域:
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
背景情况:
- 肺炎流行病 (NE),一种轻度出血性发烧与综合征 (HFRS),由Puumala病毒 (PUUV) 引起,长期后果不确定.
- 以前的研究表明可能存在脏和心血管问题,但缺乏广泛的长期数据.
研究的目的:
- 评估具有NE相关急性损伤 (AKI) 病史的个体的长期和心血管结果.
- 评估PUUV感染标志物的持久性,并在20年内确定潜在的再感染.
主要方法:
- 一组156名已确认PUUV感染和先前AKI的个人被跟踪了长达20年的时间.
- 临床评估包括血压,功能测试,尿液分析和PUUV特异性血清学.
- 患有初始功能异常的参与者经历了一年重新评估.
主要成果:
- 慢性病 (CKD) 在8%的参与者中被诊断为慢性病;在6%的参与者中存在血.
- 高血压是普遍存在的,在随访时观察到78%的个体.
- 在所有参与者中,PUUV特异性IgG抗体仍然可检测,没有IgM抗体或再感染的证据.
结论:
- 这项大型的长期研究表明,NE后的显著的长期病理并不常见.
- 在急性NE之后,CKD的发病率没有增加.
- 虽然高血压很常见,但其与之前的汉塔病毒感染的直接因果关系需要进一步调查.
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