接种COVID-19疫苗后的后急性非特异性症状:一项基于丹麦人口的研究
Christina Bisgaard Jensen1, Kristoffer Torp Hansen1, Bodil Hammer Bech1
1Department of Public Health, Aarhus University, DK-8000, Aarhus, Denmark.
International journal of epidemiology
|October 10, 2025
概括
对于大多数人来说,COVID-19疫苗接种并没有增加急性后症状. 然而,对疫苗犹不决的接种疫苗的人报告了更多的症状,可能是由于报告偏差或nocebo效应.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- 在接种COVID-19疫苗后,通常会出现疲劳和疼痛等非特异性后急性症状.
- 人们对疫苗潜在的不良反应存在担忧,特别是在不愿接种疫苗的人群中.
- 这项研究考察了COVID-19疫苗接种和后急性症状之间的关系,考虑到疫苗犹.
研究的目的:
- 调查COVID-19疫苗接种是否与急性后非特异性症状的风险增加有关.
- 为了确定这种关联是否基于个人的COVID-19疫苗犹水平而有所不同.
主要方法:
- 一项使用BiCoVac队列数据的纵向研究 (913,116名16-65岁的丹麦公民).
- 从2021年5月到2022年6月,通过国家注册表和问卷收集的数据.
- 使用身体痛苦综合征检查清单评估非特异性症状;使用后勤和线性回归模型进行分析.
主要成果:
- 在未接种疫苗的人群中,接种疫苗与接种疫苗后大多数症状的几率较低有关.
- 对疫苗怀疑的个体表现出类似的,尽管减弱的倾向.
- 与未接种疫苗的同行相比,接种疫苗的个人在接种疫苗后出现大多数症状的几率更高.
结论:
- 在大多数 (16-65岁) 个体中,没有发现COVID-19疫苗接种后急性后症状增加的证据.
- 接种疫苗的受疫苗影响的人报告了更多的症状,这表明潜在的报道偏差或nocebo效应.
- 这些发现强调了在报告疫苗不良事件时考虑心理因素的重要性.
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