基础代谢率预测社区居住的老年人痴呆症:5年纵向研究
Daiki Yamagiwa1, Osamu Katayama2, Ryo Yamaguchi2
1Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan. d.yamagiwa@ncgg.go.jp.
European geriatric medicine
|October 10, 2025
概括
低基底代谢率 (BMR) 与老年人痴呆的风险更高有关. 这一发现表明BMR可能是认知衰退的早期预测生物标志物.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 代谢过程中的代谢.
背景情况:
- 基础代谢率 (BMR) 与生理衰退有关,但其与认知功能和痴呆风险的联系尚不清楚.
- 了解影响老龄人口认知健康的因素对于制定预防策略至关重要.
研究的目的:
- 在5年时间内调查基础代谢率 (BMR) 与患痴呆症的风险之间的关联.
- 评估不同BMR计算方程对痴呆风险的预测准确度.
主要方法:
- 使用TANITA,Mifflin-St Jeor,Harris-Benedict,Cunningham方程以及NIBIOHN方法计算的BMR.
- 根据BMR将参与者分为四分之一,并使用Cox比例危险回归来评估痴呆风险.
- 采用时间依赖的接收器运行特征 (ROC) 曲线来比较BMR方程的预测性能.
主要成果:
- 在所有计算方法中,最低的BMR四分位数中的个体与最高四分位数相比,患痴呆的风险明显更高.
- 哈里斯 - 贝尼迪克特方程证明了痴呆风险的最高预测准确性,曲线下的面积为0.71.
- 低BMR,无论计算方法如何,始终与痴呆症风险比率的增加有关.
结论:
- 低基底代谢率与老年人痴呆的风险增加有关.
- BMR显示出作为痴呆症早期预测生物标志物的潜力.
- 哈里斯 - 贝尼迪克特方程是推的,因为它在预测痴呆风险方面具有卓越的性能.
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