早期生活维生素D和6-8岁的神经认知能力:随机临床试验和观察分析
Vilja Seppälä1, Samuel Sandboge2,3, Elisa Holmlund-Suila4,5
1Welfare Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland. vilja.seppala@tuni.fi.
European child & adolescent psychiatry
|October 10, 2025
概括
早期儿童服用维生素D补充剂并没有影响神经认知能力. 然而,怀孕期间母亲的维生素D水平与孩子的智商有关,低水平和高水平都与较低的分数有关,这表明维生素D对胎儿发育起着关键作用.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 关于维生素D在神经发育中的作用,存在相互矛盾的证据.
- 母婴和幼儿时期的维生素D状况是影响认知结果的潜在因素.
研究的目的:
- 调查维生素D补充剂,母亲和儿童维生素D水平与6.6-8.9岁儿童神经认知能力之间的关联.
- 检查不同维生素D3剂量对神经发育结果的影响.
主要方法:
- 一个双盲随机临床试验,涉及维生素D3补充剂 (每天400 IU或1200 IU) 给24个月以下的儿童.
- 在怀孕期间测量母亲血清25-基维生素D (25(OH) D) 和12个月和24个月的儿童血清25(OH) D.
- 评估儿童的神经认知能力,包括总智商 (IQ) 和执行功能,使用标准化测试 (WISC-IV,NEPSY-II) 和问卷 (BRIEF).
主要成果:
- 在维生素D补充组之间没有观察到神经认知能力的显著差异.
- 在12个月和24个月的儿童25度OH) D度与神经认知结果无关.
- 怀孕期间母亲的25~OH) D度与孩子的总智商有U形的关联,其中较低和较高的水平都与较低的智商得分有关.
结论:
- 早期儿童维生素D补充似乎不会影响晚年儿童的神经认知发育.
- 怀孕期间母亲的维生素D状况在胎儿神经发育中起着至关重要的作用,最佳水平对认知结果至关重要.
- 需要进一步的研究来阐明妊娠期间母亲维生素D的精确机制和最佳范围.
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