在高级上部胃肠道癌的全身治疗期间,为基于ePRO的管理途径定义关键症状参数:一项纵向研究
Xin Shelley Wang1, Mariela Blum Murphy2, Shu-En Shen3
1Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit, Houston, TX, 77030, USA. xswang@mdanderson.org.
概括
许多高级上部胃肠道癌症患者在治疗期间会出现严重的症状. 实施电子患者报告结果 (ePRO) 可以帮助管理症状负担并改善这些人的护理.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 胃肠道癌症 胃肠道癌症是什么?
背景情况:
- 先进的上部胃肠道 (UGI) 癌症需要在全身治疗期间进行密集管理.
- 评估和管理这些患者的症状负担对于治疗坚持和生活质量至关重要.
- 电子患者报告结果 (ePROs) 为持续监测提供了一个有希望的途径.
研究的目的:
- 为了研究在接受全身治疗的晚期UGI癌症患者的症状负担.
- 确定实施ePRO系统监测这些门诊患者所需的特征.
- 建立基于ePRO的护理途径,以有效评估和管理患者.
主要方法:
- 一项纵向研究涉及111名患有转移性UGI癌症的患者,正在接受全身治疗.
- 患者在12个月内反复完成了胃肠癌的MD Anderson症状清单 (MDASI-GI).
- 基于组的轨迹分析确定了持续高症状严重程度的患者.
主要成果:
- 超过55%的患者报告说,疲劳,食欲不良,麻木/刺痛和昏昏欲睡的严重程度很高.
- 超过33%的人经历了高严重程度的无法吃饭,恶心,疼痛和睡眠障碍.
- 在45%的患者中,这些8种症状的综合得分与生活质量差异相关.
结论:
- 很大一部分晚期UGI癌症患者在全身治疗期间会出现持续的,严重的症状.
- 这凸显了使用ePRO进行例行评估和管理的必要性,特别是在治疗的前12周内.
- 实施基于ePRO的监测可以促进更好的患者护理和这一队列的结果.
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