儿童类类风湿性疾病中的格里塞尔综合征作为一种很少被认可的并发症:基于病例的审查
Lutfiye Koru1, Begumhan Baysal2, Sabriye Gulcin Bozbeyoglu2
1Department of Pediatric Rheumatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Clinical rheumatology
|October 10, 2025
概括
格里塞尔综合征 (GS) 是一种罕见的部不稳定,可以在没有感染或手术的情况下发生. 仅仅是系统性炎症就可能导致GS,这凸显了儿童患有炎症和部症状的早期诊断的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 儿科 儿科 儿科
- 神经学 神经学
背景情况:
- 格里塞尔综合征 (GS) 是一种罕见的,非创伤性大西洋轴旋转亚脱位症,主要影响儿童.
- 脑脊髓炎可能导致严重的神经缺陷,包括四肢和呼吸停止.
- 通常,GS是在上呼吸道感染或头手术之后出现的,尽管存在与全身炎症疾病的关联.
研究的目的:
- 报告两例没有感染性或外科手术触发的GS病例.
- 要突出仅仅系统性炎症在引起大西洋轴心不稳定的作用.
- 审查有关GS与类风湿病相关的文献.
主要方法:
- 关于两名患有GS的儿科患者的病例报告.
- 在类风湿病的背景下对GS的文献综述.
主要成果:
- 确定了两例GS病例:一个与青少年异常性关节炎 (JIA) 相关,另一个与家族地中海热 (FMF) 相关.
- 这两种病例都没有先前的传染病或手术触发因素.
- 文献审查证实了有限但现有的GS在类风湿病的报道.
结论:
- 系统性炎症,如在JIA和FMF中看到的,可以独立地导致导致GS的atlantoaxial不稳定性.
- 临床医生应考虑在患有全身性炎症疾病的儿科患者中使用GS,即使没有感染或手术,也会出现部疼痛或结.
- 早期识别和管理GS至关重要,以防止神经系统的后果.
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