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Updated: Jan 15, 2026

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
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一个CRISPR可定制的铜协调DNA纳米平台通过循环和代谢途径操纵来增强cuproptosis

Wenxian Zhang1, Zhi-Yuan Feng1, Zhe Feng1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.

ACS nano
|October 10, 2025
PubMed
概括

这项研究引入了一种新型的铜-DNA纳米平台 (Cu-RNP),通过增强cuproptosis来增强抗瘤疗法. 通过操纵昼夜节律和代谢途径,Cu-RNP协同诱导多模式细胞死亡,以改善癌症治疗.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?这是一个DNA纳米平台.昼夜节律 昼夜节律组合疗法治疗组合治疗.这就是cuproptosis.

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