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Updated: Jan 15, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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GeoEvoBuilder:一个深度学习框架,用于高效的功能和热稳定蛋白质设计.

Jiale Liu1,2, Hantian You3, Zheng Guo1

  • 1Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

Proceedings of the National Academy of Sciences of the United States of America
|October 10, 2025
PubMed
概括

深度学习框架GeoEvoBuilder通过整合结构和进化数据,直接设计具有增强活性和稳定的蛋白质序列. 这种先进的方法加速了蛋白质工程,绕过了劳动密集型循环.

关键词:
催化效率的催化效率是什么深度学习是一种深度学习.功能性蛋白质的设计序列的新奇性 新奇性热稳定性的热稳定性

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