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来自Lactuca indica的四种新化合物可以抑制氧化的产生

Do Thi Trang1, Nguyen Thi Ha2, Ngo Anh Bang1

  • 1Institute of Chemistry, VAST, Hanoi, Vietnam.

Chemistry & biodiversity
|October 10, 2025
PubMed
概括

研究了Lactuca indica L.化合物的氧化物 (NO) 抑制. 两个化合物,马莱胺衍生物,通过抑制NO的产生,显示出作为抗炎药物的潜力.

关键词:
阿斯特拉属植物 (Asteraceae) 是一个植物.乳草 (Lactuca indica) 是一个指标植物.没有NO的抑制活性.马利胺衍生品 马利胺衍生品这种物质叫做sesquiterpene.

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科学领域:

  • 自然产品化学 自然产品化学
  • 药理学 药理学是指药理学的学科.
  • 药用植物研究 药用植物研究

背景情况:

  • 氧化 (NO) 在生理过程中起着至关重要的作用,但过度生产会导致炎症和氧化应激.
  • 乳 indica L. 是一种传统的东方药用植物,用于治疗炎症.

研究的目的:

  • 从Lactuca indica L.中分离和识别具有氧化物 (NO) 抑制活性的活性化合物.
  • 评估这些化合物作为治疗炎症疾病的治疗剂的潜力.

主要方法:

  • 从Lactuca indica L.提取物中分离了四种新的和六种已知的化合物.
  • 使用高分辨率质谱,核磁共振和电子圆二极化 (ECD) 光谱学,对新化合物的结构阐明.
  • 孤立化合物的氧化 (NO) 抑制活性的评估.

主要成果:

  • 四种新型化合物和六种已知的化合物被分离和表征.
  • 化合物2 (一种马莱胺衍生物) 和10表现出显著的氧化 (NO) 抑制活性,其半最大抑制度 (IC50) 分别为25.3和21.4μM.
  • 隔离的化合物,包括基和马利胺衍生物,代表L. indica. indica的各种主要成分.

结论:

  • 从Lactuca indica L.中分离出来的马莱胺衍生物在抑制氧化 (NO) 生产方面表现有前途.
  • 这些发现表明,马莱胺衍生物可以作为开发新型抗炎药物的化合物.