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相关概念视频

Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
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Prokaryotic Cells01:28

Prokaryotic Cells

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Prokaryotes are small unicellular organisms that include the domains — Archaea and Bacteria. Bacteria include many common microorganisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize...
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Prokaryotic Cells01:51

Prokaryotic Cells

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Prokaryotes are small unicellular organisms that include the domains—Archaea and Bacteria. Bacteria include many common organisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins....
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Bacterial Transformation01:33

Bacterial Transformation

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In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
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Transgenic Plants02:50

Transgenic Plants

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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
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Antibiotic Selection00:57

Antibiotic Selection

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相关实验视频

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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

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细菌培养的生物材料具有耐药性和按需功能.

Jeong-Joo Oh1, Franka H van der Linden1, Koray Malcı2,3

  • 1Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, Delft 2629 HZ, Netherlands.

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概括

工程生物材料 (ELM) 是通过在细菌纤维素基质中使用休眠的细菌内体来开发的. 这种方法提高了材料稳定性,并允许按需功能化,克服了传统ELM的局限性.

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Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter
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Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation
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相关实验视频

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科学领域:

  • 生物材料科学 生物材料科学
  • 合成生物学 合成生物学
  • 微生物学 微生物学

背景情况:

  • 工程生物材料 (ELM) 提供可编程功能,但由于细胞固有的"活力",寿命短,环境耐受性差.
  • 现有的ELM在实际应用中面临限制,因为它们对恶劣条件的敏感性.

研究的目的:

  • 通过将细菌内体集成到细菌纤维素基质中,开发一种具有可编程,休眠功能的新型工程材料.
  • 克服传统ELM中短细胞寿命和对恶劣环境的耐受性低的局限性.

主要方法:

  • 在工程介质中使用*Komagataeibacter rhaeticus*和*Bacillus*内体培养了一种复合材料.
  • *K. rhaeticus*产生了一种细菌纤维素 (BC) 基质,封装了休眠的 *Bacillus* 子.
  • 基因工程被用来调节子-BC矩阵结合亲和力.

主要成果:

  • 开发的材料具有休眠的*Bacillus*内体,集成在BC矩阵中,提供对恶劣环境条件的抗性.
  • 在需要时发芽的 *Bacillus* 子允许将所需的功能赋予材料.
  • 通过基因工程基因子-BC结合亲和力来实现增强的细胞负载和材料功能.

结论:

  • 这些工程材料代表了一个多功能,按需的平台,具有可编程休眠功能.
  • 潜在的应用包括生物传感器,生物催化材料和基于纤维素的复合材料的现场转化.
  • 这种方法通过提高其强度和可编程性,显著扩大了工程生物材料的实际实用性.