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Updated: Jan 15, 2026

How to Stabilize Protein: Stability Screens for Thermal Shift Assays and Nano Differential Scanning Fluorimetry in the Virus-X Project
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应用交叉相关性用于蛋白质治疗药物的热稳定性分析

Nicholas Knutson1, Jason Richardson1, Zhongqi Zhang1

  • 1Attribute Sciences, Amgen Inc., Thousand Oaks, CA, USA.

Journal of pharmaceutical and biomedical analysis
|October 10, 2025
PubMed
概括

一种新的交叉相关法增强了蛋白质热稳定性分析,超出了传统的Tm方法. 这种方法更好地区分压力后单克隆抗体的微妙变化,改善生物制药研究和候选人选择.

关键词:
可比性 可比性在DSC,纳米DSF.更高层次的结构结构.蛋白质 蛋白质 蛋白质热稳定性 热稳定性

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