在精神病和神经病患者中进行实验室压力研究:朝着达成共识的指导方针
C Broeder1, L de Nooij2, M J M van den Eijnden3
1Amsterdam University Medical Center location Vrije Universiteit Amsterdam, Department of Psychiatry, the Netherlands; Amsterdam University Medical Center location Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, the Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, the Netherlands; Amsterdam Public Health, Mental Health Program, Amsterdam, the Netherlands.
Psychoneuroendocrinology
|October 10, 2025
概括
新的指导方针为在患有精神病或神经障碍的人身上进行实验室压力诱导研究提供了最佳实践. 这些建议平衡了有效的压力诱导与参与者的安全和福祉,以提高科学有效性.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 心理生理学 心理生理学
- 临床研究方法论 临床研究方法论
背景情况:
- 急性实验室压力诱导对于了解压力在健康和疾病中的作用至关重要.
- 对于压力诱导研究的现有指导方针缺乏对患有精神病或神经系统疾病的个体的关注.
研究的目的:
- 建立对临床人群中压力诱导研究最佳实践的共识.
- 为道德和有效的压力研究制定以参与者为中心的指南.
主要方法:
- 使用德尔菲方法进行了三轮匿名在线调查.
- 一个由179名受访者 (研究人员,参与者,有实践经验的个人,医疗保健专业人员,伦理学家) 组成的多样化的小组评价了52个陈述.
- 共识被定义为≥70%的同意/不同意,达到38个陈述 (73.1%).
主要成果:
- 在38个关于临床人群应激诱导最佳实践的陈述上达成共识.
- 强调了平衡有效的压力诱导与可接受的强度的关键需要.
- 确定了建议的关键领域:协议设计,招聘,同意,压力程序和汇报.
结论:
- 制定的指导方针为未来涉及临床人群的实验室压力研究提供了实际框架.
- 强调与科学严谨性一起,参与者福祉的重要性.
- 旨在提高压力研究在弱势群体中的有效性和可比性.
相关概念视频
Introduction to Stress and Lifestyle
854
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
854
Physiological Foundation of Stress
1.1K
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
1.1K


