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基于丝的多层涂层用于ECMO空心纤维膜的抗凝和耐久性改善

Wenbo Zhang¹, Yilin Zhang¹, Chenlu Wang¹

¹Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China.

Acta biomaterialia

|October 10, 2025

概括

一种新的丝纤维蛋白涂层增强了体外膜氧化 (ECMO) 装置的耐用性和血液兼容性. 这种稳定,生物活性涂层可以提高抗血栓性能的性能,而不妨碍氧化器的功能.

科学领域:

生物材料工程生物材料工程
医疗器械涂层医疗器械涂层
血液相容性研究血液相容性研究

背景情况:

在体外膜氧化 (ECMO) 氧化器中长时间接触血液会导致由于抗凝剂涂层降解而形成血栓.
常用于抗凝的氨酸涂层在长时间的剪切应力下脱离和失活,限制了它们的长期疗效.

研究的目的:

为ECMO空心纤维膜开发一种基于丝纤维素 (SF) 的机械坚固和耐用的多层涂层.
为了提高ECMO产品的抗凝剂性能和血液兼容性.

主要方法:

层层自组装 (LbL) 用于在空心纤维膜上创建SF基础层.
氨酸和氨酸通过静电相互作用被纳入,通过交联稳定,形成SF-氨酸-氨酸复合涂层.
机械稳定性通过剪切振荡和纳米划痕测试进行了评估;血液兼容性和抗血栓疗效通过体外和体内血液循环测试进行了评估;气体交换效率在小型氧化器中进行了测试.

主要成果:

SF桥梁层显著提高了涂层的机械强度和界面粘附性.
在体外和体内实验表明出色的血红相容性,降低了血小板粘附,延长了凝血时间,增强了抗血栓性质.
涂层并没有妨碍氧化器中的血液气体交换效率.

结论:

基于SF的多层涂层提供了一种稳定且持久的解决方案,以提高ECMO设备的抗血栓性能.
这种方法可以提高机械完整性和抗凝固性能,而不损害氧化器功能,为接触血液的医疗应用提供了有前途的进步.

关键词:

涂层涂层是一种涂层.血红相容性血红相容性肝素是一种肝素.一层一层的层次.这是丝丝.

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