2001年心血管疾病成年人中阿片类药物使用趋势 - 2020年3月
1Postgraduate Year 1 (PGY-1) Pharmacy Resident, Massachusetts General Hospital; Boston, MA.
Journal of the American Pharmacists Association : JAPhA
|October 10, 2025
概括
心血管疾病 (CVD) 的成年人处方阿片类药物的整体使用情况保持稳定,但长期阿片类药物处方显著增加. 老年人 (≥65岁) 的使用也增加了,由于他们对心血管不良影响的敏感性更高,造成了风险.
科学领域:
- 心血管医学 心血管医学
- 疼痛管理 疼痛管理
- 公共卫生 公共卫生
背景情况:
- 阿片类药物可能导致严重的心血管不良影响,包括低血压和心律失常.
- 以前患有心血管疾病 (CVD) 的个人特别容易受到这些阿片类药物引起的并发症的影响.
- 关于心血管疾病人口中处方阿片类药物使用趋势的数据有限.
研究的目的:
- 分析美国成年人诊断患有心血管疾病 (CVD) 的处方阿片类药物使用的长期趋势.
- 在这个患者群体中调查短期与长期阿片类药物处方的模式.
- 检查心血管疾病患者中阿片类药物使用的人口统计和并发症特异趋势.
主要方法:
- 利用了国家健康和营养检查调查 (2001年至2020年3月) 的数据.
- 包括20岁及以上的成年人被诊断为心血管疾病 (心力衰竭,冠心病,心痛,心肌梗塞,中风).
- 采用多变量逻辑回归,调整年龄,以评估四年期的趋势.
主要成果:
- 在心血管疾病患者中没有发现任何处方阿片类药物使用的重大整体趋势 (9.4%至11.8%).
- 长期阿片类药物处方 (>90天) 的患病率显著增加,从6.6%增加到10.4%.
- 在65岁及以上的成年人中,阿片类药物的使用明显增加 (7.5%至11.3%).
结论:
- 虽然整体阿片类药物使用保持稳定,但长期处方的增加表明,心血管疾病患者的慢性疼痛负担越来越大.
- 在患有心血管疾病的老年人中观察到阿片类药物使用的增加值得注意,因为他们患心血管不良事件的风险较高.
- 这些发现凸显了需要在脆弱的心血管患者群体中仔细监测和管理阿片类药物治疗的必要性.
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