抗生素耐药性,潜在的致病细菌和相关的健康风险在地质地下水
Xiaolin Zhou1, Bingying Gao1, Huiling Cui2
1Key Laboratory of Groundwater Conservation of MWR & School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing, 100083, China; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences (Beijing), Beijing, 100083, China.
Environmental research
|October 10, 2025
概括
地下水中的地质污染为抗生素耐药性基因和病原体的庇护所. 这种双重风险突出显示了.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 地质 (Cr) 在地下水中的污染是一个全球性问题.
- 抗生素耐药性是一个主要的公共卫生问题.
- 在Cr污染,抗生素抗体和地下水中的健康风险之间的联系是不太了解.
研究的目的:
- 为了研究Cr污染的含水层中的地下水微生物群,致病细菌和抗生素抵抗体.
- 评估相关的健康风险和Cr在促进抗生素耐药性的作用.
- 为了比较浅层和深层含水层的特征.
主要方法:
- 从中国西北部的浅层 (<100米) 和深层 (>100米) 水层中采集了地下水样本.
- 大基因组测序被用来识别细菌,抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE).
- 进行了统计分析,以将Cr水平与ARG丰富度,致病细菌和MGE相关联.
主要成果:
- 检测到174个ARG,其丰度高达1.28 × 10^8个副本/L.
- 浅地下水显示与深地下水相比,ARG的丰度和相关的健康风险显著更高 (p < 0.01).
- 毒性Cr(VI) 与ARG,病原细菌和MGE的增加有关,这表明具有共同选择性的作用.
结论:
- 地质Cr污染的地下水作为ARG和潜在的病原体的储.
- 污染带来了双重风险:毒性和促进抗生素耐药性.
- 研究结果强调需要管理Cr污染,以减轻抗生素耐药性对公共健康的威胁.
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