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Updated: Jan 15, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
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In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

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一个简短的SUMOylation标签调节转录因子的活动

Antoine Y Bouchard1, Anaïs J I Vivet2, Valérie C Cabana1

  • 1Département de Chimie, Université du Québec à Montréal, Montréal, Québec, Canada; Centre d'Excellence en Recherche sur les Maladies Orphelines - Fondation Courtois (CERMO-FC), Faculté des Sciences, Université du Québec à Montréal, Montréal, Québec, Canada; Regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), Montréal, Québec, Canada.

The Journal of biological chemistry
|October 10, 2025
PubMed
概括

研究人员开发了一种新的ZNF标签,专门增加蛋白质SUMOylation. 这种方法增强了像p53这样的蛋白的SUMOylation,抑制了它们的活性,并有助于研究蛋白调节.

关键词:
SUMO E3 联酶的使用情况这就是SUMOylation的作用.在 SUMOylation 标签上,可以看到 SUMOylation 标签.这就是ZNF451的原因.在 p53 里,p53 是一个 p53 的代码.小型无处不在类修饰剂 (SUMO)转录因子的转录因子

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