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Updated: Jan 15, 2026

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拉尔杰夫抑制剂抑制RAS驱动的胰腺癌和转移

Howard Donninger1, Rachel Ferrill2, Becca von Baby2

  • 1Department of Medicine, University of Louisville, Louisville, Kentucky, USA.

The Journal of biological chemistry
|October 10, 2025
PubMed
概括

研究人员开发了第一个针对泛拉斯类 (RAL) 小GTPase交换因子 (RALGEF) 的小分子抑制剂. 这种化合物抑制了RAS/RAL信号,并在临床前模型中显示出抗瘤作用,为RAS驱动的癌症提供了新的治疗途径.

关键词:
标签: 活动 活动 活动这是一种RALGDS抑制剂.这是一种RAS蛋白质.细胞信号传递是细胞的信号传递.基激活蛋白激酶 (MAPK) 是一种激活蛋白激酶.胰腺癌是一种癌症.

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