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肠道微生物群的重塑通过FFAR2/NLRP3通路通过微生物群衍生的酸缓解老年性败血症

Guangwei Yu¹, Wenhui Xie², Jingnan Xiang³

¹Department of Emergency, Fujian Medical University Union Hospital, Fuzhou, China; Fujian Key Laboratory of Vascular Aging, Fujian Medical University, Fuzhou, China.

European journal of pharmacology

|October 10, 2025

概括

便微生物群移植 (FMT) 和酸通过恢复肠道微生物群和减少炎症来改善老年人败血症的结果. 这种方法针对FFAR2/NLRP3炎症酶轴,以保护心脏.

科学领域:

老年学是指老年学的学科.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

老年败血症患者的死亡率和易感性较高,原因是肠道失生症.
年轻捐赠者便微生物群移植 (FMT) 显示出重塑肠道微生物群和缓解与年龄有关的疾病的潜力.
来自肠道微生物群的酸可能在缓解败血症相关并发症方面发挥作用.

研究的目的:

研究老年肠道微生物群重塑通过乙酸对败血症的影响.
探索酸影响老年人败血症的潜在机制.
评估老年败血症模型中酸和FMT的治疗潜力.

主要方法:

对老年败血症患者肠道微生物群和血酸的分析.
年轻捐赠者FMT和老化败血症小鼠模型中的乙酸补充.
在FFAR2 Knockdown小鼠中评估心肌损伤和NLRP3炎症酶激活.

主要成果:

老年人败血症的特点是肠道微生物群多样性减少,埃舍里希亚-希格拉菌增加,血酸酸降低.
年轻捐赠者的FMT改善了肠道微生物群,增加了阿克尔曼西亚和便酸,增强了结肠屏障功能和结果.
乙酸干预通过FFAR2/NLRP3轴改善了肠道失调,器官功能障碍和心肌损伤.

结论:

肠道微生物群的重塑,特别是通过酸,改善了老年人败血症的结果.
酸抑制炎症反应,并通过非活化FFAR2/NLRP3炎症体来缓解心肌损伤.
恢复肠道屏障功能和调节微生物代谢物对于治疗老年人败血症至关重要.

关键词:

乙酸是一种酸.结肠的屏障功能是结肠的屏障功能.老年人的败血症.便微生物群移植便微生物群移植我们的肠道微生物群.

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