暴露会扰乱肠道微生物群的组成,代谢功能和老年小鼠的宿主肠道能量代谢
概括
暴露显著改变了老年雄性和雌性小鼠的肠道微生物组和新陈代谢. 这些发现突出了与老年人群中的相关的潜在健康风险.
科学领域:
- 环境健康 环境健康
- 微生物组研究 微生物组研究
- 毒理学 毒理学 毒理学
背景情况:
- 环境暴露,如,可以影响肠道微生物群和疾病的发展.
- 以前的研究集中在对成年雄性小鼠的影响上,而老龄化雌性小鼠的研究不足.
- 老化肠道微生物对暴露的反应需要进一步调查.
研究的目的:
- 为了研究暴露对肠道微生物群和老年雌雄小鼠宿主代谢的影响.
- 为了确定不同时间暴露于的特定微生物和代谢变化.
- 了解老年人暴露对健康的潜在影响.
主要方法:
- 年龄较大的雌性和雄性小鼠分别在2周和4周内暴露在中.
- 使用β多样性指标分析了便微生物多样性.
- LEfSe和指标分析确定了受影响的特定细菌种群.
- PICRUSt2预测了肠道微生物组的功能变化.
- 结肠和盲体样本分析了脂质和蛋白质水平,以评估代谢变化.
主要成果:
- 四周的暴露改变了两个性别的便微生物β多样性,而两周没有.
- 特定的细菌丰度,包括乳杆菌和Bifidobacterium,被暴露显著改变,以性别和持续时间依赖的方式.
- 暴露影响了肠道细菌的能量代谢途径,并增强了老年小鼠和结肠中的糖解.
- 在老年雄性小鼠的结肠中,降低了C16:1的丰度.
结论:
- 暴露于会引起老鼠肠道生态系统的重大干扰,影响微生物组成和宿主代谢.
- 这些发现表明,潜在的机制将暴露与老年人的不良健康结果联系起来.
- 需要进一步的研究,以充分阐明与老龄化人口中的暴露相关的长期健康风险.
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