瘤微环境中的B7-H3:对儿童固体瘤中CAR T细胞疗法的影响
Lena Jansen1, Judith Wienke1, Ronja Molkenbur1
1Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.
Cancer metastasis reviews
|October 10, 2025
概括
B7-H3 (CD276) 是儿童癌症中CAR T细胞治疗的有希望的标. 这篇评论探讨了瘤和瘤微环境中的B7-H3表达,并讨论了治疗的含义.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- B7同源3 (B7-H3,CD276) 是一种细胞表面蛋白质,其正常组织表达有限,在各种癌症中表达高.
- B7-H3作为免疫检查点分子起作用,但其在免疫调节中的确切作用取决于上下文,并受到争议.
- B7-H3的表达范围超越瘤细胞,包括瘤微环境 (TME) 中的细胞.
研究的目的:
- 审查小儿固体瘤和TME组件中的B7-H3蛋白表达.
- 讨论B7-H3-向化基抗原受体 (CAR) T细胞治疗在重塑TME的潜力.
- 确定改善儿童固体癌症中B7-H3向的CAR T细胞治疗的挑战和未来方向.
主要方法:
- 在小儿固体瘤中对B7-H3表达的文献综述.
- 在瘤微环境中的各种细胞类型中分析B7-H3表达.
- 讨论B7-H3 CAR T细胞对TME组件向的影响.
主要成果:
- B7-H3在TME内的瘤细胞和各种非瘤细胞类型上表达,包括免疫细胞,内皮细胞和与癌症相关的纤维细胞.
- 向B7-H3的CAR T细胞将与瘤细胞和TME组件相互作用.
- 这些相互作用预计会影响治疗性免疫反应和治疗结果.
结论:
- 针对B7-H3的CAR T细胞疗法由于其表达特征,具有针对儿科固体瘤的潜力.
- 了解TME中的B7-H3表达对于预测和优化治疗疗效至关重要.
- 需要进一步的研究来应对挑战,并完善儿童患者的B7-H3向的CAR T细胞策略.
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