由于高脂肪饮食引起的肥胖会调节MYC‒PPIL1网络,从而调节精的发生
Menghua Shi1, Lei Xu1, WeiXi Zheng1
1First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China.
Basic and clinical andrology
|October 11, 2025
概括
高脂肪饮食会导致肥胖,导致男性不育 (精). 这项研究确定了PPIL1,MYC和mTOR作为关键的分子参与者,而L-卡尼丁显示了治疗潜力.
科学领域:
- 生殖生物学 生殖生物学
- 代谢综合征是代谢综合征的一种.
- 生物信息学是一种生物信息学.
背景情况:
- 男性不孕症,特别是精 (AZS),是一个日益严重的全球健康问题.
- 肥胖,通常是由高脂肪饮食 (HFD) 驱动的,与AZS有关,但分子机制尚不清楚.
研究的目的:
- 通过生物信息学和动物模型研究参与HFD诱导肥胖导致AZS的关键基因和调控途径.
- 为了确定与HFD相关的男性不孕症的潜在治疗点.
主要方法:
- GEO转录组数据分析以确定HFD肥胖和AZS之间的差异表达基因 (DEGs).
- 拉索回归和支持向量机器 (SVM) 用于关键基因鉴定 (C1QBP,PPIL1).
- 基因转录因子联合表达网络分析 (MYC),单细胞RNA-seq,全基因组丰富分析,以及在HFD养大鼠中的验证.
主要成果:
- 确定C1QBP和PPIL1作为HFD诱导的AZS中的关键基因,MYC作为潜在的上游调节者.
- 在老鼠中,HFD诱导的肥胖会影响精子运动,降低丸激素,增加氧化应激.
- 在HFD/AZS大鼠中观察到MYC和mTOR表达的减少和PPIL1表达的增加;L-carnitine部分逆转了这些变化.
结论:
- 由HFD引起的肥胖可能会通过调节PPIL1并抑制MYC和mTOR信号通路来引起AZS.
- 这项研究强调了针对这些分子途径的潜在治疗策略,用于与肥胖相关的男性不孕症.
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