VEGFA的性别特异性签名与长期的COVID症状持续性有关
Xavier Farré1,2, Natalia Blay1,2, Susana Iraola-Guzmán1,2
1Genomes for Life-GCAT Lab, CORE Program, Germans Trias i Pujol Research Institute (IGTP), 08916, Badalona, Spain.
BMC medicine
|October 11, 2025
概括
长期的COVID与血管功能障碍有关,特别是VEGFA水平升高,特别是在绝经后的妇女中. 性别特定的蛋白质组模式表明不同的恢复途径,强调在管理长期COVID时需要考虑性和血管健康.
科学领域:
- 生物医学研究的研究.
- 蛋白质组学是指蛋白质组学.
- 免疫学 免疫学 免疫学
背景情况:
- 长期COVID呈现出持续的多系统症状,影响SARS-CoV-2感染后的几个月或几年的健康.
- 风险因素包括女性性别,先前存在的疾病,严重感染,再感染和缺乏疫苗接种.
- 了解长期COVID的机制和长期影响是一个关键的公共卫生优先事项.
研究的目的:
- 为了研究长期COVID的蛋白质组景观.
- 确定与持续症状相关的关键蛋白质生物标志物.
- 为了探索长期COVID病变发生的性别特异性.
主要方法:
- 对来自COVICAT队列的171名个体 (133名长期COVID患者) 的1395种蛋白质生物标志物的蛋白质组分析.
- 利用Olink®技术在两个时间点进行高通量蛋白质表达评估.
- 采用线性混合模型和网络分析来检查蛋白质变化,长期COVID状态和性别特异性影响.
主要成果:
- 在长期COVID患者中,VEGF-A (血管内皮生长因子A) 显著过度表达 (p=0.0013).
- 与其他组相比,绝经后妇女的循环VEGFA水平显著更高 (p=8.55×10−3).
- 网络分析强调了VEGFA的核心作用,也观察到失调的化学激素信号传递,补体激活和病毒再激活.
结论:
- 由VEGFA驱动的血管功能障碍是长期COVID的关键特征,特别是在较轻微的病例中.
- 性别特定的蛋白质组模式表明了不同的恢复机制,受女性荷尔蒙状况的影响.
- 未来的管理和长期COVID的理解应该整合性别,血管健康和疾病严重程度.
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