儿科中塞夫特里亚克松诱导的胆病:综合频率,症状和相关因素 - - 系统性审查和元分析
Tahneem Yaseen1, Khurshid Alam2, Mohammed Zawiah3
1Masters of Pharmacy (Clinical Pharmacy), Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Italian journal of pediatrics
|October 11, 2025
概括
在儿童中使用塞夫特里亚可以导致胆病 (胆结石) 在15%的病例中. 高剂量,长时间治疗和脱水是这种儿科并发症的相关危险因素.
科学领域:
- 儿童传染病 儿童传染病
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 塞夫特里亚克松是一种广泛用于治疗儿科感染的抗生素.
- 它与胆结石病 (胆结石形成) 的关联引起了重大临床关注.
- 了解频率和风险因素对于患者安全至关重要.
研究的目的:
- 为了确定儿科患者中 ceftriaxone 诱导胆病的综合频率.
- 为了识别通常与 ceftriaxone 诱导胆病的发生相关的因素.
- 评估相关因素对症状负担的影响.
主要方法:
- 在科学网络,PubMed,谷歌学者和Scopus的系统文献搜索到2024年3月.
- 包括儿童患者 (0-18岁) 患有 ceftriaxone 诱导的胆病的随机试验和队列研究.
- 随机效应元分析以估计聚合频率,并对异质性的敏感性分析.
主要成果:
- 11项研究 (1项RCT,10项队列研究) 被纳入了元分析.
- 塞夫特里亚诱导的胆病的综合频率为15% (95% CI: 9-23%),具有显著的异质性 (I2 = 81.76%).
- 相关因素包括高剂量的塞夫,长时间使用,短时间注射,脱水等. 大多数病例在停止治疗后得到解决.
结论:
- 塞夫特里亚克松诱导的胆病是儿科患者中相对常见的并发症.
- 风险因素如高剂量,延长时间和脱水增加发生.
- 建议对胆道并发症进行临床监测,并考虑替代治疗方法.
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