在接受手术的自闭症谱系障碍患者中发作结果:系统性审查和元分析
Varun R Subramaniam1,2, Jonathan Goldstein1,3, Ali Rafati4
1Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Epilepsia
|October 11, 2025
概括
手术可以显著减少发作,并改善自闭症谱系障碍 (ASD) 患者的生活质量. 在这种复杂的同时发生的疾病中,正确的患者选择是成功结果的关键.
科学领域:
- 神经科学和神经病学 神经科学和神经病学
- 发育障碍 发育障碍 发展障碍
- 手术干预 手术干预
背景情况:
- 自闭症谱系障碍 (ASD) 和经常同时发生,从而带来复杂的治疗挑战.
- 手术是对抗药性的潜在治疗方法,但ASD患者的结果是可变的.
- 现有的研究手术在自闭症患者群体的疗效需要全面的综合.
研究的目的:
- 系统地审查和分析ASD患者在各种类型的手术后的发作结果.
- 评估手术对ASD患者生活质量和神经精神症状的影响.
- 确定影响这一特定患者群体手术成功率的因素.
主要方法:
- 按照PRISMA标准进行系统审查,搜索Medline,Embase和PsycInfo数据库.
- 包括46项研究,包括325名ASD和患者.
- 对切除性手术,神经调节 (VNS,RNS,DBS) 和息性手术的结果进行分析,按发作减少和恩格尔分类进行分层.
主要成果:
- 切除术在54%的患者中实现了无发作;神经调节导致>80%的发作减少在33.5%.
- 与没有MRI异常的患者相比,MRI异常患者 (55%) 的发作自由率更高 (19%).
- 时间切除显示出比超时切除 (66%) 更高的发作自由率 (80%);大多数患者报告神经精神病学/生活质量结果有所改善.
结论:
- 这一综合性审查表明手术有很大的潜力,可以减少发作频率或在选择的ASD患者中实现无发作.
- 手术也可能导致ASD和患者的生活质量和神经精神症状的改善.
- 仔细选择患者对于优化手术在ASD患者群体中的好处至关重要.
关键词:
自闭症自闭症是什么尸体形切除术 (callosotomy) 是一个体形切除术.激光间歇性热疗法是一种激光间歇性热疗法.通过神经调节进行神经调节.切除性手术是切除性的手术.迷走神经刺激 迷走神经刺激更多相关视频
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