大脑网络的皮质下枢纽 维持人类意识
Morgan K Cambareri1,2, Andreas Horn1,3,4, Laura D Lewis5,6,7
1Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Human brain mapping
|October 11, 2025
概括
研究人员在健康个体中绘制了皮质下大脑连接的地图,以确定意识障碍 (DoC) 的治疗目标. 在中脑,丘脑和脑干中确定了关键枢纽,为神经调节疗法提供了新的目标.
科学领域:
- 神经科学是一个神经科学.
- 功能神经成像 功能神经成像
- 神经调节是一种神经调节.
背景情况:
- 下皮层网络枢纽的神经调节显示出治疗意识障碍 (DoC) 的前景.
- 对于有效的治疗刺激的最佳皮质下标仍然不完全理解.
- 了解皮下连接对于推进DoC治疗至关重要.
研究的目的:
- 在健康成年人中绘制皮质下连接与正规皮质网络的地图.
- 识别功能地连接到多个皮质网络的皮质下枢纽.
- 为DoC提供针对性神经调节策略的证据.
主要方法:
- 利用了来自168名健康受试者的7台特斯拉休息状态功能性MRI (rs-fMRI) 数据 (人类结合体项目).
- 应用Nadam-Accelerated SCAlable and Robust (NASCAR) 张量分解来绘制连接的地图.
- 分析了六个皮质网络和皮质下区域之间的功能连接.
主要成果:
- 确定了腹膜区域 (VTA) 和胸膜核 (中央侧面,副筋) 作为关键的皮质下枢纽,连接到多个皮质网络.
- 发现了与唤醒核相关的,与昏迷相关的病变相关的,在特脑脑层中的皮质下枢纽.
- 发现脑干/thalamic核和默认模式/ Salience 网络之间的功能联系,突出了它们在意识中的作用.
- 在基底和中部叶观察到额外的枢纽,包括尾状头部,面,杏仁体,海马体和末的床核.
结论:
- 多个在脑干,乳头,基底和中部叶的多个皮质下枢纽显著调节皮质功能.
- 腹部体区域 (VTA),乳头内膜内核和脑体被强烈支持作为恢复意识的治疗点.
- 发布了皮质下连接地图,以促进正在进行的意识障碍治疗神经调节的研究.
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