局部灰色物质体积差异与立体电脑学定义的发性之间的关联
Jacob Bunyamin1, Benjamin Sinclair1,2, Thanomporn Wittayacharoenpong1,2
1Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Victoria, Australia.
Epilepsia
|October 11, 2025
概括
灰质体积 (GMV) 的差异与患者的发性区域 (EZ) 相相关. 在MRI阳性病例中,增加的GMV与EZ接触有关,而在MRI阳性病例中,中部区域显示在EZ接触附近的GMV减少.
科学领域:
- 神经成像是一种神经成像.
- 的研究研究.
- 量化MRI是指数量化的MRI.
背景情况:
- 基于voxel的灰色物质体积 (GMV) 量化在识别发性区域 (EZ) 中取得了中等成功.
- "基本真相"的定义可能会影响EZ识别中的GMV的准确性.
- 立体电脑图 (SEEG) 提供了详细的电生理学数据,用于定位发作发作.
研究的目的:
- 调查转基因病毒差异与SEEG定义的性致病性之间的关联.
- 探索GMV作为EZ的潜在成像生物标志物.
- 评估GMV在患者中区分EZ与其他大脑区域的有用性.
主要方法:
- 包括50名SEEG患者和51名对照患者,在T1加权的MRI扫描上执行基于voxel的顺序推断.
- 根据EZ定义 (射频热凝) 和活性刺激区 (前10%的HFO) 进行SEEG接触分类.
- 利用混合效应的物流回归和性能分析来评估转基因病毒与EZ和刺激区的关联.
主要成果:
- 在整体队列 (OR 1.21) 和MRI阳性组 (OR 1.45) 中,增加的GMV与EZ接触相关,但不是MRI阴性.
- 降低的GMV与MEZ接触者在半叶时区域 (OR0.53) 相关,而在新皮层区域 (OR1.32) 发现GMV增加.
- 在MRI可见的病变中,增加的GMV与EZ接触积极相关 (OR1.50). 在MRI阳性病例中,增加的GMV与新皮层刺激区接触有关.
结论:
- 当地GMV差异与整个队列和MRI阳性患者中的EZ接触有关.
- 关联因地区而异,在新皮质中具有积极的联系,在间隙时结构中具有负面联系.
- 在MRI可见的病变内增加的GMV是与EZ接触相关的重要发现.
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