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Updated: Jan 15, 2026

Identification and Characterization of Protein Glycosylation using Specific Endo- and Exoglycosidases
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一种可逆的化学酶标记策略,用于对蛋白质O-葡萄糖化进行分析

Shilin Zhang1,2,3, Yinping Tian1,2, Yuqiu Wang4

  • 1State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Angewandte Chemie (International ed. in English)
|October 11, 2025
PubMed
概括

O-链接葡萄糖 (O-Glc) 是一种蛋白质修饰,可以在正规和非正规蛋白质中找到. 一种新的化学酶法揭示了O-Glc是人类细胞中广泛存在的翻译后修饰.

关键词:
化学酶标签的使用方法末端葡萄糖化酶的使用方法葡萄糖蛋白质组的基因组.O-GLcc 是一个O-GLc.蛋白质的糖化化是蛋白质的糖化.

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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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